Also known as: Parasitic roundworm infection
A Vietnam veteran presents with respiratory distress from dormant strongyloides worms reactivated by steroid use. Despite treatment attempts including ECMO, the hyperinfection proves fatal, driving an emotional storyline with Sharon Goodwin about her first love.
Also known as: Heart valve infection
A woman found disoriented by police is diagnosed with endocarditis causing micro-strokes to her brain. The case becomes central to a debate between Dr. Charles and surgeons about informed consent for emergency surgery, with the bacteria ultimately identified as Q fever from dairy farm exposure.
The causative organism for Pamela's endocarditis is identified as Q fever, contracted from working on a dairy farm. This infectious disease requires public health reporting.
Also known as: Nosebleed
A tech entrepreneur with persistent nosebleeds is treated via house call app. Dr. Halstead suspects but ultimately rules out naegleriasis (brain-eating amoeba) from lake swimming, though the case highlights concerns about concierge medicine.
Also known as: Stomach pain
A human trafficking victim presents with stress-related abdominal pain after being kicked out of a shelter. The case focuses on his psychological trauma and Dr. Reese's attempts to find him safe housing, with Danny ultimately fleeing the hospital.
Also known as: TB
April mentions her TB is remaining inactive as context for accepting Tate's marriage proposal. At episode's end, she develops fever and cough, suggesting possible TB reactivation in a cliffhanger ending.