Also known as: Liver failure
Carol Manning (Natalie's mother) develops acute liver failure, likely triggered by interaction between trial medication and underlying chronic Hepatitis C. This drives a major subplot involving Will's unauthorized drug use and multiple emergency interventions.
Also known as: Liver inflammation
Carol's previously asymptomatic chronic Hepatitis C is discovered during workup for acute liver failure, revealing she was carrying the virus long-term and it was pushed into acute decompensation by drug interaction.
Also known as: Blood around the heart
Carol develops cardiac tamponade during a biventricular pacing procedure when the catheter wire perforates her heart, requiring emergency pericardiocentesis to prevent cardiac arrest.
Carol develops a prolonged QT interval on EKG, making her a candidate for biventricular pacing as a bridge to heart transplant.
Also known as: Brain tumor
An 18-year-old pianist with a cranial hemangioblastoma refuses surgery due to fear of cognitive and functional deficits. She develops acute intracranial bleeding requiring emergency decompression and ultimately consents to definitive surgery.
Also known as: Brain bleed
Mindy develops acute bleeding from her brain tumor causing rapid deterioration and requiring emergency burr hole decompression to relieve pressure.
A lung transplant recipient develops severe bilateral pneumonia eight days post-transplant. Investigation reveals the donor lungs had residual COVID-19 damage making them susceptible to infection, requiring emergency surgery to salvage one lung.
James experiences severe post-transplant complications due to receiving lungs with microscopic COVID-19 damage that was undetectable at time of transplant, leading to rapid bilateral pneumonia and near-complete lung failure.
Also known as: PTSD
Dr. Archer continues his treatment for PTSD from military service by attending a veterans therapy group, where he hears stories that he later adapts to help a patient.
Ramona reveals a history of childhood sexual abuse by her father. Despite claiming to have processed it, she becomes suicidal and attempts to jump from a building before Dr. Charles intervenes and connects her with a specialized trauma facility.
Also known as: Suicide attempt
Ramona experiences acute suicidal crisis and attempts to jump from a building ledge before Dr. Charles talks her down and arranges admission to a specialized treatment facility for trauma survivors.