Also known as: GBM, terminal brain cancer
This episode depicts the final days of Mark Greene's life as he travels to Hawaii with his daughter Rachel while dying from recurrent glioblastoma. His condition has progressed to the point of frequent seizures, severe headaches, difficulty writing, and he ultimately dies at the end of the episode.
Also known as: Seizure
Mark experiences a grand mal seizure while in Hawaii with Rachel, requiring an increase in his Dilantin dosage to 400mg. His daughter finds him seizing, which is a traumatic event that drives plot tension.
Also known as: Heroin addiction
Rachel is confronted by Mark about using Ecstasy and stealing his Vicodin pills. This represents a significant subplot as Mark tries to address his daughter's substance abuse issues in his final days, reflecting concerns about what will happen to her after he dies.