TvDx
ER

ERNBC

Season 12, Episode 5

10 medical diagnoses portrayed

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Prostate cancersupporting

Also known as: Prostate cancer

Referenced in the opening recap as a previously diagnosed condition discovered through PSA screening and needle biopsy, showing moderately differentiated prostate cancer.

Recurring storyline

Also known as: Preventive breast removal

Enlarged lymph node discovered during surgeryPsychological traumaBody image disturbance

Patient with strong family history of breast cancer (mother's sister and grandmother died of breast cancer) who underwent prophylactic bilateral mastectomy. During attempted reconstruction, surgeons discovered an enlarged lymph node, raising concern for possible cancer spread. Patient experiences severe emotional distress and psychological crisis post-surgery.

ER — S12E05Patient: Stephanie Lowenstein

Also known as: Coma

Awakening after prolonged comaMuscle atrophySeizure disorderReturn to unresponsive state

Young woman who awakened from a four-year coma following a violent carjacking and assault. Initially showing remarkable recovery with experimental cocktail (fluoxetine, Sinemet, dextroamphetamine), she experiences a sudden seizure and returns to an unresponsive state after learning details about her traumatic accident.

ER — S12E05Patient: Blaire Collins

Patient stabbed in the neck by his girlfriend, presenting with zone two neck injury. Used as a teaching case by Dr. Clemente to discuss asymptomatic vascular injuries and management of penetrating neck trauma.

ER — S12E05Patient: Tony Dejesus

Also known as: Head trauma

Altered mental statusDrug intoxication

Patient who fell approximately 20 feet after standing up on an amusement park ride (Tilt-A-Whirl). Presented with severe agitation and altered mental status, initially suspected to be on drugs but later diagnosed with anticholinergic toxicity from dextromethorphan (cold pills/'skittles').

ER — S12E05Patient: Tommy Bonetti

Also known as: Skittles overdose

TachycardiaMydriasisAgitationHyperchloremia with reversed anion gap

Anticholinergic toxicity from recreational use of cold pills containing dextromethorphan hydrogen bromide ('skittles'). Diagnosis confirmed by characteristic lab finding of reversed anion gap (bromide mimicking chloride). Treated with physostigmine.

ER — S12E05Patient: Tommy Bonetti

Also known as: Spinal cord damage

Spinal shockHypotension

Seven-year-old girl with crush injury presenting with spinal shock and high thoracic injury at T4 sensory level. Required intubation and vasopressor support.

ER — S12E05Patient: Lola Simon

Also known as: Pseudotumor cerebri

Young woman with recurring headaches and history of idiopathic intracranial hypertension. Used as teaching case for non-invasive diagnosis using intraocular pressure measurement and modern understanding of sagittal sinus thrombosis as underlying cause.

VomitingDiarrheaVariable cardiovascular effects (tachycardia/bradycardia, hypertension/hypotension)

Group of Zen monks who developed toxicity after making tea from tobacco plant (tabaco gigante) growing in their garden. Presented with inconsistent toxidrome showing mixed autonomic effects.

Also known as: Seizure

Postictal stateReturn to unresponsive state

New-onset seizure in patient recently awakened from prolonged coma, possibly triggered by medication changes, withdrawal, or psychological stress. Treated with Ativan but followed by return to unresponsive state.

ER — S12E05Patient: Blaire Collins