Also known as: PTSD
Owen experiences violent nightmares from his Iraq war service, resulting in him choking Cristina while asleep. This drives a major subplot about whether their relationship can continue and Owen's need for treatment.
Also known as: Skin cancer that has spread
Izzie has stage-four metastatic melanoma with lesions in her brain and liver. This episode focuses on her brain surgery to remove a metastatic lesion, with planning for future surgeries and aggressive treatment including radiation, chemotherapy, and immunotherapy.
Also known as: Brain tumor
Derek performs a craniotomy to resect a metastatic melanoma lesion from Izzie's brain. The surgery is the central medical event of the episode and successfully removes the tumor with clear margins.
Also known as: Liver metastases
Izzie has metastatic lesions on her liver that will require future surgical resection by Dr. Bailey as part of her comprehensive cancer treatment plan.
Also known as: Heart stopped
Elderly patient repeatedly experiences cardiac arrest and is resuscitated multiple times during the episode. Her family is waiting for her to die, but she continues to survive. Eventually dies at the end of the episode, with her pacemaker briefly masking her death.
Also known as: Head laceration
Motorcycle accident victim without helmet arrives via helicopter with massive head trauma and lost vital signs en route. Declared DOA. This case triggers Owen's PTSD freeze response.
Also known as: Colorectal cancer
Bailey performs a colectomy and discovers an unexpected fist-sized mass requiring mobilization of the superior mesenteric artery before resection and bowel reconnection. Used as a teaching case for Izzie.