Also known as: Skin cancer that has spread
Izzie is undergoing high-dose IL-2 chemotherapy for her metastatic melanoma, which causes severe side effects throughout the episode. Despite her deteriorating condition, she tries to maintain normalcy by planning Meredith's wedding.
Also known as: PTSD
Owen continues therapy for PTSD related to his military service. He struggles to identify and name his feelings, particularly shame over having attacked Cristina during a nightmare.
Six-year-old Jessica dies from Tay-Sachs disease after her father struggles to accept that experimental treatment in Mexico won't save her. Arizona helps the father accept his daughter's imminent death so he can be present for her final moments.
Also known as: Kidney injury from bus accident
Driver who swerved to avoid a pedestrian and hit a pole, sustaining abdominal injuries with bleeding around his spleen. Mark Sloan manages the abdominal trauma while Derek and Mark compete over surgical priorities.
The car accident patient sustained damage to his facial nerve from a broken temporal bone, requiring nerve repair surgery by Derek Shepherd.
Also known as: Perforated eardrum
The patient's ruptured eardrum from the car accident requires ossicular reconstruction by Mark Sloan to prevent permanent hearing loss.
Also known as: Fractured cheekbone
ZMC (zygomaticomaxillary complex) fracture of the temporal bone sustained in the motor vehicle accident.
Also known as: Broken arm
Pedestrian who jumped in front of a car sustained a fractured humerus with bruising, though maintained good pulses.
Also known as: Suicide attempt
Patient who deliberately jumped in front of a moving car in an apparent suicide attempt. Meredith orders a psychiatric consult but the patient leaves before evaluation, then jumps from a height causing massive trauma.
Also known as: Impalement near aorta
After jumping from a height, the patient sustained a rib fracture that protruded into his ascending aorta, causing massive bleeding. George performed an emergency thoracotomy and clamped the injury, saving the patient's life.
Also known as: Blood in chest cavity
Bilateral chest tubes were inserted for bleeding in the chest cavity following the patient's fall.