Also known as: Bone cancer
Hunter Martinez, a 20-year-old minor league baseball player, is diagnosed with osteosarcoma of the distal right femur. He undergoes a rotation-plasty procedure after completing three months of chemotherapy, which he kept secret from his mother to avoid worrying her.
Also known as: Blood clot in lung
Frank Nelstadt presents with fever, sore throat, and productive cough, but develops a massive pulmonary embolism. He coughs up a bronchial tree-shaped blood clot and requires intubation and placement of a catheter to break up the clot.
Also known as: Blood clotting disorder
Frank is diagnosed with Factor V Leiden, a genetic blood-clotting disorder that caused his abnormal amount of blood clots. His daughter Ella is tested for the condition to determine which of her two fathers is her biological parent.
Also known as: Manic depression
DeLuca's father is suspected of having untreated bipolar disorder by his daughter Carina. He experiences manic episodes with grandiose ideas and cycling moods, though he refuses treatment and describes himself as someone who 'feels the world deeply.'
Also known as: Early-onset Alzheimer's
Ellis Grey appears in flashback sequences showing progressive memory loss and confusion, including not recognizing people and making strange statements. She appears to Maggie in a dream providing cryptic medical insights.