Dr. Ezra Powell, a renowned cancer researcher, presents with respiratory failure and fluid-filled lungs. The team eventually diagnoses amyloidosis type AA, a terminal condition where abnormal proteins build up in organs, explaining his multi-system organ failure. This drives the central ethical conflict of the episode regarding assisted death.
Also known as: Fluid in the lungs
Powell's lungs are full of fluid, causing severe shortness of breath and inability to oxygenate properly. This is a primary symptom that drives the initial diagnostic workup and stress testing throughout the episode.
Also known as: Collapsed lung
During the open lung biopsy surgery, Powell develops a pneumothorax on the right side with air building up in his chest and compressing his heart, requiring emergency decompression.
Also known as: Nerve damage, numbness
Testing reveals Powell has lost sensation in his left leg, abdomen, and right arm, indicating the amyloidosis is also attacking his peripheral nerves in a patchy distribution.
Also known as: Chronic leg pain
House's leg pain has returned and he is using his cane again, with the team noticing and expressing concern. This represents a worsening of his chronic pain condition and suggests possible regression in his recovery.
Also known as: Cold
A clinic patient presents with congestion, fever, aches, weakness, and loss of appetite after traveling to Fresno. House diagnoses a rhinovirus (common cold).