Also known as: Motion blindness
Kyle presents with intermittent inability to see moving objects and seizures. The team initially investigates various causes including infection, tumor, and genetic conditions before ultimately diagnosing ragged-red fiber disease.
Also known as: Mitochondrial myopathy
House discovers Kyle has inherited ragged-red fiber disease from his mother's side, which is transmitted through mitochondrial DNA. This causes muscle weakness, poor coordination, and severe cardiomyopathy requiring a heart transplant.
Also known as: Liver failure
Kyle develops acute liver and kidney failure during treatment, initially attributed to his alcoholism combined with anti-seizure medications, but ultimately related to his underlying genetic condition.
Also known as: Coma
Kyle's father Gabriel has been in a vegetative state for 10 years following smoke inhalation during a house fire. House temporarily revives him using experimental drugs to obtain family medical history needed to diagnose Kyle.
Also known as: Heart failure
Kyle develops severe cardiomyopathy secondary to his ragged-red fiber disease and chronic alcoholism, ultimately requiring a heart transplant from his father to survive.
Also known as: Alcoholism
Kyle's chronic alcohol abuse, stemming from guilt over his mother's death, significantly contributed to his liver damage and complicated his underlying genetic condition.
Also known as: Heroin addiction
Detective Tritter's investigation into House's Vicodin addiction continues as a recurring subplot, with interrogations of House's team and Wilson about prescription practices and drug-seeking behavior.