Also known as: CGD
An 18-year-old guardian of his siblings presents with multiple opportunistic infections after his parents' death. The emotional trauma triggered his underlying genetic immunodeficiency (chronic granulomatous disease), leading to repeated life-threatening infections including brain abscesses. Diagnosis is made by deliberately infecting him with different pathogens to determine which type causes the worst response, revealing CGD when serratia causes severe lung damage.
Also known as: Liver inflammation
Initially diagnosed as the primary cause of Jack's persistent vomiting and symptoms, treated with IVIG. Later revealed to be one of multiple opportunistic infections secondary to his underlying immunodeficiency.
Also known as: Fungal lung infection
Aspergillus fungal infection creates multiple abscesses throughout Jack's brain, initially mistaken for metastatic cancer. The fungal infection flourished after antibiotics and IVIG created an environment conducive to fungal growth, causing seizures.
Also known as: Heart attack
Jack presents initially with a heart attack while working at a children's restaurant. Chase performs cardiac catheterization with ergonovine to test for coronary vasospasm, which is ruled out. The heart attack is later attributed to electrolyte imbalance from persistent vomiting.
Also known as: DIC
Jack develops coagulopathy (elevated PT/PTT) causing spontaneous bleeding, a complication of his multiple severe infections overwhelming his immune-compromised system.
Also known as: Bone infection
Infection spreads to Jack's bones, weakening them to the point where minimal pressure during a lumbar puncture causes a rib fracture, indicating systemic spread of infection.