Also known as: Full-thickness burns
Derek suffered third-degree burns over 54% of his body a year prior to the episode, requiring extensive skin grafts and multiple surgeries over six months. The burns to his genitals caused testicular trauma leading to hormonal issues.
Also known as: Low testosterone with testicular shrinkage
Initially diagnosed as the cause of Derek's temperature swings and disorientation, attributed to testicular trauma from burns. Presented with high estrogen and low testosterone levels, treated with testosterone pellets.
The actual diagnosis causing Derek's symptoms. A spinal tumor pressing on nerves to the vocal cords (causing voice changes) and on the meningeal branch of the vertebral artery, obstructing blood flow to the brain and causing false memories and neurological dysfunction. Removed surgically.
Also known as: Broken heart syndrome
Initially thought to be the primary diagnosis - Derek experienced multiple heart attacks triggered by stress and emotional pain from being in love with his brother's fiancée Amy, exacerbated by his hormonal imbalance. Later revealed to be a red herring caused by the actual underlying meningioma.
Also known as: Heroin addiction
House faces criminal charges for stealing oxycodone and is required to enter drug rehabilitation. The episode follows his attempt at detox and rehab, though he is revealed to still be taking Vicodin at the end, with his buprenorphine being secretly swapped for Vicodin.