Also known as: Flu medication overdose
Amber took amantadine for flu symptoms, but her kidneys (destroyed in the bus crash) could not filter the drug, leading to toxic accumulation. This caused progressive multi-organ failure including tachycardia, hepatic failure, and ultimately irreversible heart damage leading to her death.
Also known as: Kidney failure
Amber lost both kidneys in the bus crash trauma, requiring dialysis. This renal failure prevented her body from filtering out the amantadine she had taken for flu symptoms, leading to fatal drug toxicity.
Also known as: Rapid heart rate
Amber's heart rate reached 130 bpm and wouldn't slow down, caused by amantadine toxicity. The prolonged tachycardia led to ventricular fibrillation and ultimately irreversible structural damage to her heart.
Also known as: V-fib
Amber's tachycardia degenerated into ventricular fibrillation, requiring the team to use therapeutic hypothermia and bypass to prevent brain death while searching for a diagnosis.
Also known as: Liver failure
As the amantadine toxicity progressed, Amber developed hepatic failure evidenced by jaundice, indicating the poison was spreading to multiple organ systems.
Also known as: Severed femoral artery
Amber's femoral artery was damaged in the bus crash and required surgical repair as part of her initial trauma management.
Also known as: Head laceration
House suffered head trauma in the bus crash leading to skull fracture and amnesia. His attempts to recover memories through deep brain stimulation widened the fracture, causing a brain bleed and seizure, leaving him comatose.
Also known as: Memory loss
House lost four hours of memory from the night of the bus crash, preventing him from initially identifying Amber as the critically ill patient. He used risky procedures including hypnosis and deep brain stimulation to recover the memories.
Also known as: Heart attack
House mentions having had a heart attack in the morning, likely related to the stress and injuries from the bus crash, limiting his ability to take additional medications.
Also known as: Fractured skull
House's skull fracture from the bus crash was worsened by the seizure during deep brain stimulation, leading to a brain bleed.
Also known as: Brain bleed
The seizure during deep brain stimulation widened House's skull fracture, causing a brain bleed that left him in a coma with uncertain prognosis for cognitive recovery.
Also known as: Seizure
House suffered a complex partial seizure during deep brain stimulation, with violent shaking that widened his skull fracture and caused a brain bleed.