Also known as: Whitmore's disease
The central case of the episode. A patient with chronic undiagnosed illness holds the clinic hostage at gunpoint demanding diagnosis. His symptoms include dyspnea, fatigue, heart palpitations, insomnia, rash, facial nerve palsy, and hypocalcemia. House ultimately diagnoses melioidosis, a bacterial infection contracted in Florida that explains all symptoms and has been protected against kidney damage by his long-term use of proton pump inhibitors.
Also known as: Huntington's disease
Thirteen's ongoing Huntington's disease becomes plot-relevant when she volunteers to test dangerous medications on herself first, later explaining she has 8-10 years to live. House suggests her risk-taking is a manifestation of her disease and a desire to hasten death. She suffers acute kidney injury from the combination of experimental drugs administered during the hostage crisis.
Also known as: Kidney failure
Thirteen develops acute kidney injury after being forced to take dexamethasone and other experimental medications during the hostage crisis. Her pre-existing Huntington's disease made her kidneys more vulnerable. She requires a week of temporary dialysis but is expected to recover.
Also known as: GSW
A hostage in the clinic is shot in the lower limb by the armed patient early in the hostage crisis as a demonstration of the gunman's seriousness. The wound is described as a flesh wound.