Also known as: Locked-in state
Lee presents after a motorcycle accident with complete paralysis except for eye movements. Initially thought to be brain death, House recognizes locked-in syndrome. The episode centers on determining the underlying cause while Lee can only communicate by blinking.
Also known as: Rat disease
The ultimate diagnosis causing Lee's locked-in syndrome. Contracted from rat urine in a friend's basement where Lee was secretly staying, the infection entered through a small cut and destroyed his liver, releasing toxins that caused demyelination and locked-in syndrome.
Also known as: Liver failure
Lee's liver failure, caused by leptospirosis, is the key mechanism leading to his locked-in syndrome. House deduces the liver has already failed when enzymes appear normal, comparing it to a sunken ship no longer sending SOS signals. The itching foot provides the crucial diagnostic clue.
Also known as: Heart stopped
Lee experiences cardiac arrest when demyelination affects the area of his brainstem controlling heart rhythm. The team successfully resuscitates him and places a temporary pacemaker.
Also known as: Corneal ulcer
Lee develops a corneal ulcer due to inability to blink and properly lubricate his eyes while locked-in. This complication rules out cadmium poisoning as the cause of his condition.
Also known as: Head injury
Lee's initial presentation following a motorcycle crash. Initially presumed to be the cause of his locked-in state, but House determines the brain damage actually caused the crash rather than resulted from it.
Also known as: Scraped elbow
House presents to the ER with minor injuries from a motorcycle accident, leading him to be placed as Lee's roommate and becoming involved in the diagnostic case.