Video game developer presents with burning hand pain, cardiac issues (thickened left ventricle), priapism, fever, and inability to prune in water. Initially misdiagnosed as multiple conditions (CRPS, thrombocytosis, amyloidosis) before Fabry disease is confirmed through observation of lack of finger pruning and fat deposits in kidneys.
Also known as: Heart failure
Patient develops pulmonary edema during spinal stimulation procedure when his thickened left ventricle causes increased pressure in the lungs as heart rate climbs. This cardiac manifestation leads to discovery of systemic disease.
Also known as: Prolonged erection
Patient develops prolonged painful erection lasting over three hours requiring surgical shunt to drain blood. This vascular symptom helps narrow differential diagnosis and ultimately points toward metabolic disease.
Also known as: Chronic leg pain
House's chronic leg pain flares up significantly after leaving Mayfield psychiatric facility. His struggle to manage pain without returning to Vicodin addiction is a central arc of the episode, driving his attempt to find new coping mechanisms and ultimately his decision about returning to diagnostic medicine.
Also known as: Heroin addiction
House's ongoing recovery from Vicodin addiction is central to the episode. He nearly relapses, struggles to find alternative coping mechanisms, and has his urine tested by colleagues suspicious of his use. His addiction and recovery ultimately influence his decision about returning to diagnostic medicine.
Also known as: Swollen lymph nodes
Patient develops facial swelling from enlarged lymph nodes, initially thought to be a new symptom but later identified as iodide mumps (reaction to CT contrast), which helps eliminate lymphatic disease from differential and leads to correct diagnosis.