Also known as: GPA
The central diagnosis of the episode. Performance artist Afsoun Hamidi was initially misdiagnosed with primary CNS lymphoma and given a terminal prognosis. House eventually discovers she has Wegener's granulomatosis, a treatable autoimmune condition causing blood vessel inflammation throughout her body, explaining her brain mass, pancreatitis, and skin lesions. She initially refuses radiation therapy to preserve her cognitive abilities for her art, but ultimately accepts treatment.
Also known as: CNS lymphoma
Initial misdiagnosis given to the patient four months prior at another hospital. She was told it was inoperable and terminal, which motivated her to create her final art piece. This drives the plot until House discovers the correct diagnosis of Wegener's granulomatosis.
Also known as: Self-injury
Recurring issue from previous episode. House recently cut into his own leg in self-destructive behavior following his breakup with Cuddy. He's just had surgery to remove a drain and is recovering. Multiple characters express concern about his self-destructive behavior and opioid use throughout the episode.
Also known as: Heroin addiction
House's chronic Vicodin dependency is confronted by Wilson, who notices House taking excessive amounts (half a month's supply in three days). Wilson suggests House is using medication to avoid dealing with emotional pain rather than physical pain. This ongoing struggle is part of House's character arc throughout the episode.