Season 8, Episode 1

Also known as: Mast cell disease

A prisoner presents with joint pain, fever, eyebrow loss, osteopenia, and anaphylactic shock triggered by heat/hot liquids. House diagnoses systemic mastocytosis and risks his parole to perform a dangerous aspirin challenge test to confirm the diagnosis, ultimately triggering another attack that proves him correct.

Also known as: Opioid addiction

House's ongoing Vicodin addiction drives a major subplot as he faces an 'exit tax' from fellow inmates demanding 20 Vicodin pills before his release. His withdrawal symptoms are visible throughout the episode as he tries to survive on reduced doses, creating desperation that influences his actions.