TvDx
House

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Season 8, Episode 16

5 medical diagnoses portrayed

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Also known as: MFS

Ascending paralysisOphthalmoplegiaRespiratory compromise

The central diagnosis of the episode. A 22-year-old hockey enforcer presents with hemoptysis, later developing ophthalmoplegia and ascending paralysis. The team eventually discovers Miller Fisher syndrome caused by Epstein-Barr virus, which was successfully treated with plasmapheresis after multiple misdiagnoses.

House — S08E16Patient: Bobby (hockey enforcer)

Also known as: Mono

Hepatic steatosisSplenomegaly

The patient contracted mononucleosis from Epstein-Barr virus, which explained his enlarged spleen and liver. This infection ultimately triggered the Miller Fisher syndrome that caused his paralysis.

House — S08E16Patient: Bobby (hockey enforcer)
Hemoptysissupporting

Also known as: Coughing up blood

The presenting symptom that brought the patient to the hospital. Initially attributed to hockey injuries, it was later understood to be part of the broader infectious and autoimmune process.

House — S08E16Patient: Bobby (hockey enforcer)

Also known as: Fatty liver disease

Hormonal changesGynecomastia

The patient's enlarged liver caused hormonal imbalances leading to breast development and emotional lability, which were mistaken for other conditions before the correct diagnosis was established.

House — S08E16Patient: Bobby (hockey enforcer)
Splenomegalysupporting

Also known as: Enlarged spleen

Discovered on CT scan, the enlarged spleen was a key finding that led the team through various differential diagnoses including leukemia and DVT before arriving at the correct diagnosis of EBV infection.

House — S08E16Patient: Bobby (hockey enforcer)