Also known as: Broken heart valve
Jozette, a 32-year-old Haitian aid worker, collapses with extreme shortness of breath and chest pain after learning about a mudslide in her village. Her mitral valve is torn, causing blood to back up into her lungs. She undergoes emergency cardiac surgery to repair the valve after multiple cardiac arrests.
Also known as: Broken heart syndrome
The emotional trauma from the mudslide disaster causes Jozette's heart to beat so hard that it tears the muscles holding her mitral valve together, leading to acute mitral regurgitation requiring emergency surgery.
Also known as: Multiple drug overdose
Leo, a 10-year-old boy, is on four psychiatric medications (zotepine, sertraline, zolpidem, atomoxetine) that are causing serious side effects including diabetes, bed-wetting, and lethargy. Dr. Frome fights to take him off all medications to address the underlying psychological trauma from witnessing his father's death.
Also known as: Grief and anger from trauma
Leo experiences violent outbursts at school stemming from unprocessed grief and guilt over his father's death. He blames himself for his father's fatal heart attack, as his father had climbed five flights of stairs to retrieve forgotten LEGOs. The episode centers on getting him off medications so he can receive proper talk therapy.
Also known as: Type 2 diabetes
Leo develops Type 2 diabetes as a side effect of his psychiatric medications, specifically the combination of antipsychotics and stimulants, which is causing his bed-wetting symptoms.
Also known as: Terminal cancer
Max is secretly dealing with his own cancer diagnosis while running the hospital. Dr. Sharpe urges him to tell his pregnant wife Georgia about his condition, but he has been avoiding doing so.
Max's wife Georgia is experiencing spotting during her pregnancy and requires bed rest to prevent complications. She must avoid physical and emotional stress to protect herself and the baby.
Also known as: Cancer not responding to treatment
Millie is a cancer patient whose chemotherapy has not been effective. Dr. Sharpe discusses changing her treatment regimen. Millie struggles with the physical effects including hair loss and severe nausea.