Also known as: TB
Esau is diagnosed with multidrug-resistant tuberculosis (MDR-TB) while preparing to marry his pregnant girlfriend. The diagnosis threatens his immigration status and ability to be present for his child's birth, forcing him into isolation and creating a central conflict when he and his partner flee the hospital.
The unborn baby of Elisha and Esau has a congenital heart defect requiring surgery within a week of delivery and multiple follow-up procedures, which prevents the family from relocating to Kenya where advanced cardiac care would be unavailable.
Also known as: Sperm allergy
May develops a severe allergic reaction to her new boyfriend Henry's seminal fluid, experiencing anaphylaxis after intercourse. The condition threatens their relationship and requires careful management. Dr. Wilder proposes desensitization therapy over 6-12 months as a potential treatment.
Also known as: PTSD
Natasha is a plane crash survivor (Flight 97) working with Violet on overcoming her fear of flying. She has a severe panic attack on a plane, requiring removal before takeoff. She carries guilt about not saving a fellow passenger during the crash. By episode's end, she successfully flies to San Francisco after therapy with Sheldon.