Also known as: Ovarian cancer
Susan's ovarian cancer has returned with bloating and weakness. She chooses to proceed with her wedding to Bizzy rather than pursue treatment, having signed a DNR. This drives the emotional core of the episode as Addison keeps the secret from Bizzy.
Also known as: COPD
Abe has COPD with severe chronic cough from years of smoking cigars. He refuses proper medical care and continues unhealthy habits, creating conflict between him, his daughter Lisa, and Sam who tries to help him.
Also known as: PTSD
Charlotte continues to struggle with PTSD following her rape, experiencing intrusive memories during intimacy, sadness, fear, and sleep disturbance. She seeks therapy but is only offered medication, which she rejects.
Also known as: Depression
Charlotte exhibits symptoms of depression including persistent sadness, difficulty sleeping, and lack of energy as aftermath of her sexual assault trauma.
Also known as: Psychosis
Sheldon's mentor Larry has developed a psychotic disorder, abandoning his talk therapy practice to only prescribe pills, experiencing auditory hallucinations, and having a psychotic break at dinner. He is involuntarily committed at episode's end.