Also known as: Schizoaffective disorder
Wes is a schizophrenic patient and artist who stops taking all his medications after Dr. Turner (Violet) is suspended. He experiences severe paranoid delusions about machines controlling people's minds, leading to a psychotic episode and collapse on the street. His mother refuses long-term institutionalization despite medical recommendations.
Also known as: Thickened heart muscle
Wes has underlying hypertrophic cardiomyopathy that goes unmedicated when he stops taking his heart medications, leading to arrhythmia and collapse during his psychotic episode.
Also known as: Huntington's disease
Michelle is a 30-year-old woman with early-onset Huntington disease (CAG count 43) who has rapidly progressing symptoms. She requests physician-assisted suicide from Amelia, changes her mind during the attempt when she has an adverse reaction to benzodiazepines, but ultimately dies by intentional overdose of oxycontin.
Also known as: Diminished ovarian reserve
Addison begins IVF treatment (step one - ovarian stimulation with hormone injections) to attempt pregnancy despite having very high FSH levels. This is a continuing storyline about her struggle with infertility and desire to have a child.
Also known as: Alcoholism
Michelle mentions she struggles with alcohol use disorder daily, forming a 'buddy system' with Pete where they support each other through their respective substance use challenges.
Also known as: Heroin addiction
Amelia reveals she struggles daily with drug addiction as part of her conversation with Michelle about their mutual challenges and forming a support system.