Also known as: Heroin addiction
Amelia Shepherd is revealed to be actively using opioids (oxycodone) and lying about being sober. The entire episode centers on an intervention staged by her colleagues, her denial and withdrawal symptoms, and her eventual agreement to enter a 50-day inpatient rehabilitation program after her fiancé Ryan dies of an overdose.
Also known as: Narcotic overdose
Ryan, Amelia's fiancé and fellow addict, dies from an opioid overdose. Amelia finds him unresponsive, and his death becomes the catalyst for her decision to enter rehabilitation treatment.
Also known as: HLH
Toby, a foster child with lupus, develops hemophagocytic lymphohistiocytosis, a condition where immune cells attack his own body. He presents with fever, abdominal pain, liver failure signs, and bleeding. Cooper treats him with chemotherapy and stem cell transplant.
Also known as: Lupus
Toby has pre-existing lupus diagnosed four years prior, which triggers the development of hemophagocytic lymphohistiocytosis requiring aggressive treatment including stem cell transplant.
Also known as: OHSS
Addison collapses at the practice due to a rare complication of fertility treatment where her abdomen fills with fluid secondary to hormonal stimulation. Jake aspirates the fluid and she proceeds with frozen embryo transfer despite Sam's objections.