Also known as: Heroin addiction
The entire episode centers on Amelia's opioid addiction crisis. She disappears for 12 days on a drug bender, lies about being sober, and the practice stages an intervention. She eventually admits herself to rehab after her fiancé Ryan dies of an overdose.
Also known as: Narcotic overdose
Ryan, Amelia's fiancé and fellow addict, dies from an opioid overdose. His death becomes the catalyst for Amelia finally agreeing to enter rehab treatment.
Also known as: HLH
Toby, a foster child with lupus, develops hemophagocytic lymphohistiocytosis where his immune cells attack his own body. He requires chemotherapy and stem cell transplant, creating conflict when Cooper must miss his son's play to perform the life-saving procedure.
Also known as: Lupus
Toby has a four-year history of lupus which triggers the development of hemophagocytic lymphohistiocytosis requiring aggressive treatment.
Also known as: OHSS
Addison collapses from fluid accumulation in her abdomen as a rare complication of her fertility hormone treatments. Jake aspirates the fluid and she proceeds with frozen embryo transfer despite Sam's objections.
Also known as: Diminished ovarian reserve
Addison's ongoing struggle with infertility continues as she learns her first IVF attempt failed and proceeds with frozen embryo transfer, creating significant strain in her relationship with Sam who doesn't want children.
Also known as: Blocked arteries
Pete has follow-up evaluation showing good cardiac recovery post-bypass surgery with normal function, but he remains emotionally disconnected from Violet, leading to their separation discussion.