Also known as: Newborn heroin withdrawal
Newborn Eli is brought in by his teenage sister with severe symptoms from opioid withdrawal after his mother used drugs during pregnancy. He requires methadone tapering and intensive care.
Also known as: CCAM
Baby Eli has a congenital lung malformation requiring emergency surgical removal of damaged lung tissue. Addison performs a lobectomy to resect the affected area, with plans for healthy tissue to regenerate.
Also known as: Brain tumor
Erica is undergoing chemotherapy for her brain tumor, but Amelia researches alternative treatments and proposes an experimental surgery in Seattle that could potentially cure rather than just buy time. The episode focuses on whether to tell her son Mason about her terminal diagnosis.
Also known as: Heroin addiction
Eli's mother Melissa is a recovering opioid addict who left her newborn to detox cold turkey in a motel room for eight days. The episode explores whether she can be trusted to care for her baby after getting clean.
Also known as: Manic depression
Sam's sister Corinne returns after 20 years, heavily medicated in prison. Sheldon takes her off multiple psychiatric medications to make a proper diagnosis. She has a history of extreme mood swings, from manic behavior to severe depression and suicidal ideation, though her exact diagnosis remains unclear.