Also known as: Seizure
Kaye presents with new-onset tonic-clonic seizures at an audition. Initially treated with lorazepam and stabilized. The seizures are ultimately determined to be caused by emboli from a cardiac tumor rather than epilepsy or infection.
Also known as: Valley fever meningitis
Initially suspected as the cause of Kaye's seizures given her recent arrival from the desert (Albuquerque). Brain lesion was found and treated with antifungals, but this turned out to be a misdiagnosis as the true cause was cardiac.
Also known as: Heart tumor
Amelia's critical catch reveals that Kaye has a tumor in the left atrium of her heart, which was breaking apart and throwing emboli to her brain, causing both the brain lesion and the seizures. This becomes the definitive diagnosis requiring cardiac surgery.
Also known as: Meningitis
James recounts saving a chef's daughter who presented with high fever and vomiting. His intern diagnosed flu, but James had an instinct to do a spinal tap which revealed bacterial meningitis.
James references a case where Amelia correctly diagnosed a spinal infection against his initial recommendation to discharge, demonstrating her clinical instincts.
Also known as: Prostate cancer
Sheldon reveals to Amelia that he has prostate cancer during a heart-to-heart conversation about relationships. He states he is fine or hopes to be fine, and uses his diagnosis to illustrate what truly matters in life.
Also known as: Heroin addiction
Amelia's recovery from alcohol and oxycodone addiction is a central theme. She is 407 days sober and navigating second-year sobriety while beginning to date again and managing fears about relapse in the context of new relationships.