Season 5, Episode 6

Mrs. Wilk is diagnosed with systemic amyloidosis affecting her liver, with the disease expected to eventually shut down all her organs. The diagnosis drives a major subplot about end-of-life care miscommunication, as J.D. mistakenly assumes she wants to die peacefully rather than pursue aggressive treatment.

Also known as: Chronic leg pain

Mr. Peele presents with chronic pain lasting three months with no identifiable medical cause despite extensive testing and exploratory surgery. The episode focuses on the difficulty of diagnosing and treating pain when no physical cause can be found, with the doctors initially doubting the reality of his symptoms until committing to further investigation.