Season 5, Episode 17

Also known as: Liver scarring

Frank Coleman has hepatitis causing severe liver damage with jaundice. Despite suppressive therapy, his condition progresses to end-stage liver failure requiring a liver transplant from his brother Marc.

Also known as: Bleeding after surgery

Marc Coleman, the liver donor, develops life-threatening bleeding after partial liver donation when a suture comes undone. He becomes hypotensive and tachycardic, requiring emergency return to the OR to repair the bleeding.

Also known as: Blood cancer

Referenced in the opening as J.D. mentions he shaved his head a month ago to show solidarity with a leukemia patient. This sets up the episode's opening but is not the main medical focus.