Also known as: Varices from liver scarring
Mitchell Stewart is admitted for liver shunt surgery due to idiopathic portal hypertension. His liver continues to deteriorate post-surgery, and it's eventually discovered he's been unknowingly poisoning himself with sildenafil (marketed as herbal supplements) which his compromised liver cannot process.
Also known as: Ruptured appendix
Lily presents with fever and loss of appetite but doesn't recognize she's in danger because she cannot feel pain. Her appendix has ruptured, causing widespread infection that necessitates emergency surgery and eventually leads to amputation of her infected hand.
Also known as: Pain insensitivity
Lily's brain doesn't process pain signals - either physical or emotional. FMRI testing reveals no activity in pain-processing regions when stimulated. This condition prevented her from recognizing her appendicitis. She ultimately chooses to take naloxone to gain the ability to feel pain after her husband leaves her, wanting to experience emotional depth.
Also known as: Liver poisoning from medication
Mitchell's liver damage is caused by daily ingestion of sildenafil (Viagra) disguised as herbal supplements. His pre-existing liver condition made him vulnerable to the toxic effects of the medication at doses that wouldn't harm most people.
Also known as: Sleep apnea
Dr. Glassman observes a man at City Hall who appears to have sleep apnea, falling asleep on what should be an important day. This is a brief observational diagnosis mentioned in passing during the marriage license scene.