Also known as: Kidney tumor
Ryan is a teenage patient with a Wilms tumor being treated with chemotherapy. The tumor responds so well to chemo that it completely disappears, eliminating the need for surgery and allowing him to attend prom with his girlfriend Angie.
Also known as: GBM, terminal brain cancer
Angie is a teenage patient with a recurrent stage 3 brain tumor that has infiltrated her thalamus and fornix. The tumor is inoperable without causing severe neurological damage. She experiences seizures and ultimately dies despite the surgical attempt. Her story drives the emotional core of the episode, particularly her desire to attend prom with her boyfriend Ryan.
Also known as: Lymphatic swelling
James is an ultra-marathoner who develops severe lymphedema caused by a genetic mutation in his ARAF gene. The condition causes fluid accumulation throughout his body, including around his heart. The team uses zebrafish models to test multiple medications to find the right treatment.
James has a genetic mutation on his ARAF gene that creates excessive kinase enzyme, causing cellular overproliferation in his lymphatic system. This was triggered by a stress fracture and threatens to cause him to 'drown from the inside' if not properly treated.
Also known as: Chronic depression
James was diagnosed with persistent depressive disorder at age 16. He manages it with antidepressants and running, which he credits with saving his marriage and his life. This condition adds urgency to treating his lymphedema so he can return to running.
Also known as: RA
Glassman is taking methotrexate for his rheumatoid arthritis, which is working well for his joint symptoms but causing severe nausea. He has stopped eating solid food at work to avoid vomiting. The episode addresses his need to switch medications to continue functioning as a surgeon.
Also known as: Fluid around the heart
James develops pericardial effusion as a complication of his lymphedema and ARAF mutation, causing chest pain and tachycardia. The team performs an emergency pericardial tap to drain the fluid.
Also known as: Stomach ulcer
James develops an ulcerative lesion in the antrum of his stomach causing upper GI bleeding as a side effect of the MEK inhibitor Binimetinib. The team performs endoscopy to cauterize the bleeding vessel.