Also known as: Blood collection
Patient presents with a hematoma from a ski trip injury that requires drainage, which leads to the discovery of an underlying thyroid cancer compressing nearby blood vessels.
Also known as: Thyroid cancer
Hannah's third cancer diagnosis (following melanoma and breast cancer). The thyroid tumor causes tracheal compression requiring emergency surgery. Later revealed to be part of Li-Fraumeni Syndrome, a genetic predisposition to multiple cancers throughout life.
Also known as: LFS
Genetic diagnosis explaining Hannah's multiple cancer occurrences (melanoma, breast cancer, thyroid carcinoma). Combined with environmental toxin exposure (TCE from Silicon Valley chip-making), creates lifelong cancer risk requiring constant surveillance.
Also known as: Frostbite
Patient develops frostbite from staying too long in a cryotherapy booth during self-care life-extension regimen.
Also known as: Perforated intestine
Wyatt's bowel perforates suddenly, requiring immediate emergency surgery. This is the first manifestation of complications from his experimental CRISPR gene therapy.
Also known as: Congenital colon nerve disorder
Adult presentation of Hirschsprung disease discovered during surgery, caused by CRISPR gene modification gone wrong. Normally only seen in babies and young children, making this a singular presentation requiring removal of dilated colon.
Also known as: Nerve damage from gene editing
Central condition of the episode: Wyatt undergoes experimental CRISPR gene therapy in China to extend lifespan by optimizing telomerase activity. Instead, causes a novel polyneuropathy with amyloid-like deposits along nerves, producing widespread bilateral pain, autonomic dysfunction, and risk of permanent disability. Team proposes reversing CRISPR with herpes simplex virus delivery mechanism.
Also known as: Ruptured spleen
Wyatt's spleen ruptures as a complication of the CRISPR-induced polyneuropathy with amyloid-like deposits, requiring emergency splenectomy.