Also known as: Heart failure
Jack, a 12-week-old baby, has severe cardiomyopathy requiring a heart transplant. His condition has worsened significantly, making him the top candidate for a donor heart. The transplant surgery is central to the episode's main medical storyline.
Also known as: Aortic stenosis
Eden, Morgan and Alex's 11-week-old daughter with Turner syndrome, has rapidly progressing aortic stenosis with severe valve dysfunction requiring urgent surgery. The Ross Procedure is aborted when surgeons discover insufficient tissue, leading to the innovative Domino Transplant solution.
Also known as: Skin infection
Jack develops cellulitis and an abscess behind his ear from a fingernail scratch. The infection must be cleared immediately or he will be ineligible for the heart transplant. Shaun uses medical maggots for rapid debridement.
Eden's underlying Turner syndrome is mentioned as a factor that increases her risk for complications from ECMO and other interventions. It's part of her overall complex medical picture requiring the heart valve surgery.
Also known as: Brain attack
Referenced in the 'Previously on' segment, Dr. Glassman's recent stroke is part of his ongoing medical arc that led to his resignation. This affects his relationship with Shaun and his professional role in this episode.