Also known as: Superbug fungal infection
EMT Sophia contracts deadly Candida auris after transporting Dawn Long from LTACH. Despite antifungal treatment, she deteriorates into septic shock and dies, becoming the central tragedy of the episode and exposing a hospital cover-up.
Also known as: DKA
Sophia presents with DKA due to poorly managed diabetes, which also compromises her immune system and makes her vulnerable to the Candida auris infection.
Also known as: Lymphoma
Derek, undergoing chemotherapy for aggressive B-cell lymphoma, develops pulmonary edema and fluid overload requiring intubation and mechanical ventilation. The episode focuses on his emotional preparation with his family before being sedated.
Also known as: Fluid in the lungs
Derek develops pulmonary edema as a complication of chemotherapy, gaining five pounds of fluid with kidneys not recovering, necessitating mechanical ventilation.
Also known as: Scarring of the lungs
Isaac, a homeless EMT, is diagnosed with genetic pulmonary fibrosis (indicated by premature gray hair). He requires lung transplant but lacks a support system, leading to Conrad and others volunteering to help him.
Also known as: Collapsed lung
Isaac develops a pneumothorax due to a kinked chest tube, causing acute respiratory distress and hemodynamic instability before the team discovers and fixes the problem.
Also known as: Life-threatening infection
Sophia deteriorates into septic shock from the Candida auris infection despite maximum medical therapy including pressors and multiple antifungals, ultimately leading to her death.
Also known as: Liver poisoning from medication
Sophia develops acute liver injury, likely as a side effect of the antifungal medication, which initially leads the team to consider adult-onset Still's disease before confirming Candida auris.
Also known as: Outer ear infection
Sophia's ear infection is the key diagnostic clue that leads Conrad to correctly identify Candida auris, as the fungus was first discovered in ear infections.
Isaac is mentioned as having cardiovascular disease that requires him to quit smoking, though this is secondary to his pulmonary fibrosis diagnosis.