Also known as: Ruptured spleen
Curtis Warren presents with syncope and hypotension after fainting during a camping trip. CT reveals massive splenomegaly due to splenic vein thrombosis, leading to intra-abdominal bleeding requiring emergency splenectomy. The condition is later revealed to be a complication of unsupervised hormone therapy for gender transition.
Also known as: Brain bleed
Hillary sustains a subdural hematoma after deliberately falling down concrete stairs to avoid accepting a marriage proposal. She requires emergency neurosurgery to repair the bleeding artery under her skull.
Hillary sustains a right knee fracture along with a wrist fracture from her fall down the stairs, requiring orthopedic repair after her brain surgery.
Also known as: Transgender
Curtis reveals she is transgender and transitioning to live as Rosalind, having been taking unsupervised estrogen therapy purchased off-shelf. This drives the major emotional arc of the episode centered on her brother Ben's reaction and acceptance.
Also known as: Brain cancer
Dr. Herman's inoperable brain tumor continues to be monitored by Dr. Shepherd, with imaging showing slight inferior growth but still within expected margins. Herman's behavioral changes (furniture theft, flirting) prompt concern about tumor progression.