Charlotte presents with progressive multi-organ failure including epiglottitis, muscle wasting, splenic rupture, and hepatic failure. The team eventually diagnoses visceral leishmaniasis contracted during a secret trip to Rio, but the diagnosis comes too late and she dies despite treatment.
Eddie was initially diagnosed with lung cancer and heart failure, but House discovers pulmonary nodules indicating a rare fungal infection. The cardiac blastomycosis is curable with itraconazole, but Eddie initially refuses treatment wanting to die to donate his liver to his wife Charlotte.
Also known as: Airway blockage
Charlotte's initial presentation involves acute respiratory failure with epiglottitis, which was the first manifestation of her underlying visceral leishmaniasis.
Kutner is found dead from a self-inflicted gunshot wound to the right temple with no warning signs or suicide note. His death is central to the episode as House and the team struggle to understand why he killed himself, with House initially theorizing murder before accepting the suicide.
Also known as: Alcohol poisoning
A young girl presenting with altered mental status before a beauty pageant is diagnosed as intoxicated from drinking her mother's mouthwash, treated simply by withholding further alcohol.
Also known as: CHF
Eddie's heart failure was initially thought to be terminal from lung cancer, but was actually a complication of his underlying cardiac blastomycosis, which is curable.