Also known as: GBM, terminal brain cancer
Joe is a stage four glioblastoma patient in a clinical trial (C-22) that is being shut down due to the hospital sale. The episode centers on his and his wife Natalie's struggle with whether to transfer to Mayo Clinic or accept end-of-life care. Joe ultimately asks Bernie to help him die while he's 'still himself,' and Bernie provides enough morphine for Joe and his wife to manage his death on their own terms.
Also known as: AIDS
Thor reveals that his new husband Reuben has HIV but is undetectable on medication, allowing them to expect a long life together. This is presented as a positive example of modern medicine's success, contrasting with Joe's terminal situation.
Also known as: Type 1 diabetes
Thor mentions he is a type one diabetic and is the healthiest he's ever been, describing himself as a 'miracle of modern medicine' when discussing his marriage and Reuben's HIV status.